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Buy 4-PrO-DMT online, also known as 4-Propionoxy-DMT, or O-Propionylpsilocin, or 4-Propionoxy-N,N-dimethyltryptamine, is a tryptamine psychedelic that shares similarities with other well-known substances like psilocybin and DMT. 4-PrO-DMT is a derivative of DMT, with a propionoxy group attached to its molecular structure.


CAS # – 1373882-11-1

Purity: ≥98.8%

WARNING This product is NOT for human or veterinary use

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Psychedelics have captivated human curiosity for centuries, and 4-PrO-DMT is one of the lesser-known substances gaining attention. This compound, also known as 4-Propionoxy-N,N-dimethyltryptamine, is a tryptamine psychedelic that shares similarities with other well-known substances like psilocybin and DMT. In this article, we delve into the details of 4-PrO-DMT, exploring its history, chemistry, effects, and potential therapeutic applications.

History of 4-PrO-DMT

Early Discoveries and Synthesis

4-PrO-DMT was first synthesized by chemists interested in exploring the structural analogs of naturally occurring tryptamines. While it is a synthetic compound, its effects and structure are closely related to naturally occurring psychedelics like psilocybin, found in magic mushrooms, and DMT, present in ayahuasca brews.

Rise in Popularity

The resurgence of interest in psychedelics for therapeutic and recreational purposes has brought compounds like 4-PrO-DMT into the spotlight. While it remains less known compared to its counterparts, anecdotal reports and experimental research have begun to shed light on its unique properties.

Chemistry and Pharmacology

Molecular Structure

4-PrO-DMT is a derivative of DMT, with a propionoxy group attached to its molecular structure. This slight modification influences its pharmacokinetics and effects, distinguishing it from other tryptamines.

Mechanism of Action

Like other psychedelics, 4-PrO-DMT primarily interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor. This interaction leads to altered perceptions, mood, and cognition, characteristic of psychedelic experiences. The exact nuances of its pharmacology are still under investigation, but preliminary findings suggest similarities with other well-studied psychedelics.

Effects and Experiences

Onset and Duration

The effects of 4-PrO-DMT are typically felt within 20 to 40 minutes of ingestion, with the peak experience occurring around 1 to 2 hours. The total duration of effects can last between 4 to 6 hours, depending on the dosage and individual metabolism.

Subjective Experiences

Users of 4-PrO-DMT report a range of subjective experiences, including:

– Visual and Auditory Hallucinations: Enhanced colors, patterns, and sounds.
– Altered Sense of Time: Time may appear to slow down or speed up.
– Emotional Intensity: Heightened emotions, ranging from euphoria to introspection.
– Spiritual Insights: Many users describe profound spiritual or mystical experiences.

These experiences can vary widely based on the setting, dosage, and individual psychology.

Potential Therapeutic Applications

Psychedelic-Assisted Therapy

The therapeutic potential of psychedelics is a growing area of research. Studies on substances like psilocybin and MDMA have shown promise in treating conditions such as depression, anxiety, and PTSD. While specific research on 4-PrO-DMT is limited, its structural and experiential similarities suggest it may have similar benefits.

Mental Health Treatment

Psychedelics are believed to promote neuroplasticity, helping the brain to form new connections. This can be particularly beneficial for individuals with mental health conditions where rigid thought patterns are problematic. 4-PrO-DMT could potentially be explored for its ability to facilitate breakthrough experiences and emotional processing.

Legal Status and Safety

Legal Considerations

The legal status of 4-PrO-DMT varies by country. In many places, it is not explicitly scheduled but may fall under analogue laws that regulate substances similar to prohibited drugs. It is essential to research and understand the legal implications in your specific region before considering use.

Safety Profile

As with any psychedelic, safety is a paramount concern. Potential risks include:

– Psychological Distress: Bad trips can lead to anxiety, panic, and confusion.
– Physical Safety: Impaired judgment can lead to accidents or injuries.
– Mental Health Risks: Individuals with a history of mental health issues should approach with caution, as psychedelics can exacerbate underlying conditions.

Harm reduction practices, such as having a sober trip sitter and using in a safe environment, are crucial for minimizing risks.


4-PrO-DMT is a fascinating psychedelic with unique properties and potential benefits. While it remains less studied than some of its counterparts, the growing interest in psychedelic research may soon provide deeper insights into its therapeutic applications and effects. As with any substance, it is important to approach 4-PrO-DMT with respect, awareness, and a commitment to safety. Whether for personal exploration or potential therapeutic use, this compound represents a intriguing frontier in the realm of psychedelics.

Additional information


50 grams

2 reviews for 4-PrO-DMT

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  2. Kevin Deary

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